New schedule for tobramycin administration

new hepatitis b vaccine schedule for children with celiac disease

Tobramycin Disposition in the Rat Lung Following Airway Administration

Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.

BACKGROUND AND METHODS We conducted two multicenter, double-blind, placebo-controlled trials of intermittent administration of inhaled tobramycin in patients with cystic fibrosis and Pseudomonas aeruginosa infection. A total of 520 patients (mean age, 21 years) were randomly assigned to receive either 300 mg of inhaled tobramycin or placebo twice daily for four weeks, followed by four weeks wit...

Tobramycin disposition in the rat lung following airway administration.

A realistic ex vivo model, the isolated perfused rat lung (IPRL), was used to investigate tobramycin's pulmonary disposition at typical therapeutic concentrations. Different nominal doses were administered in aqueous solution to the airways alongside nonbinding absorption markers, fluorescein and mannitol. The mean fraction of each administered dose reaching the perfusate (Fp) was determined as...

A New Technique for Proppant Schedule Design

This study introduces a novel methodology for the design of the proppant pumping schedule for a hydraulic fracture, in which the final proppant distribution along the crack is prescribed. While the design is based on the assumption that the particles have relatively weak impact on the fracture propagation, the validity of this assumption can be tested a posteriori. This makes it possible to rel...